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Nutritional
Assessment Procedures
Nutritional
markers are most effectively used in a comprehensive
screening and ongoing evaluation program that help in
making decisions about nutritional support. The following
provides an algorithm for the most effective use of
these markers in conjunction with other parameters.

Adapted
from Brugler, DiPrinzio, and Bernstein 1999
The generalized
algorithm presented above applies to medical patients;
certain special patient classes should be assessed based
on the chart below:
Nutritional
Assessment: Special Cases
| Class |
When
to Assess |
| Trauma Patients
|
72 hours after stabilization |
| Surgical Patients |
Pre-operatively and
> 72 hours after surgery |
| Chronic Renal Failure Patients |
Post-dialysis |
Provided
as a courtesy by Robert G. Martindale, MD, PhD
Ongoing assessment
performed according to the algorithm should demonstrate
significant improvement over time. In particular, the
prealbumin level should increase with aggressive nutrition
support at a rate of 1 to 2 mg/dL per day, until the
patient reaches the acceptable range. If this doesn't
occur, other markers should be used to evaluate the
possibility of complications, including infection and
anastomatic breakdown.
The
Value of Visceral Protein Testing
Rapid identification
of malnutrition in hospitalized patients and the resultant
treatment intervention has been shown in recent studies
to optimize patient outcomes and reduce the cost of
care (Brugler 2002).
| “Several
well-documented methods of assessing malnutrition
risk are limited to detecting physically manifested
changes related to nutrition status. Thus, they
miss an estimated 25% of cases that could benefit
from earlier detection and treatment.” |
L
Brugler, et al. Clin Chem Lab Med. 2002. |
In a recent
study by Brugler et al., abnormal levels of prealbumin
together with normal or abnormal levels of albumin were
associated with higher hospital costs and worsened health
outcomes. The following graph depicts the costs for
the total care of patients in relation to their prealbumin
and albumin levels. Of the four categories, category
II showed (Brugler 2002):
- The highest mean cost for total care
- The highest mean complication rate during hospitalization
(0.5 complications/patient)
- The highest readmission rate (19.4% readmitted
in 31 days)
- The highest percentage of patients receiving registered
dietician care (77.4%)

Category I = Normal ALB/Normal Prealbumin
Category II = Abnormal ALB/Abnormal Prealbumin
Category III = Normal ALB/Abnormal Prealbumin
Category IV = Abnormal ALB/Normal Prealbumin
Categories
III and IV also demonstrated higher costs of hospital
care when compared to category I, indicating the usefulness
of albumin and prealbumin as independent markers for
identifying patients with malnutrition.
| “Recent technical developments
in the laboratory now permit ready access to more
sensitive visceral protein assays that more specifically
detect nutrition deficiencies and reflect the response
to treatment.” |
L Brugler, et al. Clin
Chem Lab Med. 2002.
|
Visceral
proteins, such as prealbumin, C-reactive protein and
retinol-binding protein, have shorter half-lives than
albumin; therefore, because they are more reactive to
physiological changes in the body, they may be more
valuable in identifying malnutrition earlier.
Rural
American Hospitals
The benefit
of visceral protein testing is not limited to urban
or even suburban facilities. Healthcare professionals
are also starting to recognize how rural hospitals can
benefit from these useful markers of malnutrition.
One protocol
for visceral protein testing was developed for Native
Americans in an Indian Health Services hospital, designed
to enhance the detection of malnutrition. (Bickford/2000)
The goal—devise a system that integrates observation
(patient histories) with automation (visceral protein
testing). These separate entities would work together
to more accurately and rapidly identify malnourishment,
and would ease the time constraints of registered dieticians
in Native American hospitals.
Diagnosis
consists of two points of evaluation. The first is a
1-month baseline collection of data on all consecutively
admitted, adult, nonmaternity patients identified to
be at moderate or severe risk for malnutrition. The
second is 2 weeks of automated testing of the visceral
proteins, prealbumin, C-reactive protein and retinol-binding
protein. Continuous therapy and monitoring is warranted
until patients are discharged (Bickford/2000).
The treatment
algorithm adopted by this Native American hospital can
be enlarged by clicking here.
Visceral
Protein Testing Algorithm

Current statistics still associate malnutrition with
a 25% morbidity rate and a 5% mortality rate, along
with prolonged LOS. The rapid identification of patients
who would benefit most from nutrition restoration during
hospitalization is the key to (Bickford 2000):
- Improved patient outcomes
- Reducing the cost of care
- Maximizing care reimbursement
- Fulfilling regulatory requirements
Much education
is still required to bring an overall awareness of the
problems associated with malnutrition to this type of
isolated society, and there is a distinct need for increased
staffing and higher salaries to bring about improvement
in the quality of healthcare (Bickford 2000).
For additional
information on the nutritional assessment of patients
with malnutrition, click
here.
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